United States securities and exchange commission logo May 24, 2024 Troy Ignelzi Chief Financial Officer Rapport Therapeutics, Inc. 1325 Boylston Street, Suite 401 Boston, MA 02215 Re: Rapport Therapeutics, Inc. Registration Statement on Form S-1 Filed May 17, 2024 File No. 333-279486 Dear Troy Ignelzi: We have reviewed your registration statement and have the following comment. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe a comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to this letter, we may have additional comments. Registration Statement on Form S-1 filed May 17, 2024 Risks Associated With Our Business, page 7 1. We note your revised disclosure at the bottom of page 29 in response to prior comment 1. Please add a new Summary risk factor bullet point that highlights this specific risk. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Refer to Rules 460 and 461 regarding requests for acceleration. Please allow adequate time for us to review any amendment prior to the requested effective date of the registration statement. Troy Ignelzi Rapport Therapeutics, Inc. May 24, 2024 Page 2 Please contact Jenn Do at 202-551-3743 or Daniel Gordon at 202-551-3486 if you have questions regarding comments on the financial statements and related matters. Please contact Tamika Sheppard at 202-551-8346 or Joe McCann at 202-551-6262 with any other questions. Sincerely, FirstName LastNameTroy Ignelzi Division of Corporation Finance Comapany NameRapport Therapeutics, Inc. Office of Life Sciences May 24, 2024 Page 2 cc: Justin Platt FirstName LastName